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This solution offers advantages for the following functional areas:

Adonat® is the commercially stable form of S-Adenosyl-L-methionine (SAMe), a natural molecule recognized as the most active methyl donor produced in the human body, essential to sustain the normal function of the one carbon metabolism pathway.

SAMe is involved in more than one hundred biochemical pathways and it has been shown to have mood enhancing, hepatoprotective and pro-joint activities.

The diet cannot provide adequate quantities of SAMe and decreased or low SAMe levels in some biological fluids and tissues are associated with altered body states, often accompanied by severe physiological complications. Supplementation of SAMe has been largely evaluated with impressive literature extending back more than three decades.

Adonat® results from more than 30 years of expertise and more than 10 patents, where the state-of-the-art industrial manufacturing has never given up on innovation and research and has achieved proprietary stabilization of salts and the production of innovative forms of oral dosage covered by several granted patents and patent pending applications.

Gnosis is the worldwide leader of SAMe production from a selected highly productive yeast using fermentation technologies, which generate a superior quality of the ingredient.

Adonat® is offered in worldwide markets, for pharmaceutical, nutritional and veterinary applications with peerless quality profile:

  • Highest potency of SAMe ion and highest content of the biological active form, the (S,S) active diastereoisomer >75%. (S,S) may degrade rapidly and passively converts in the inactive (R,S) form, which results in the loss of activity of the product
  • The longest available shelf-life in the market: 36 months at RT
  • GMP Manufacturing, FDA Inspected
  • DMF availability
  • US, European, Japanese Patents

Gnosis has different formulations and products covered by several granted patents and patent pending applications: