The main supplementation of folates has been represented by folic acid but recent studies have shown that (6R,S) and (6S)-5-methyltetrahydrofolate can be used as a valid alternative to folic acid, offering relevant advantages.

The biochemical pathways for the biotrasformation of folates involves a series of enzymatic reactions and cofactors. Absorbed folates are metabolized in intestinal mucosal cells though a reduction and methylation to (6S)-5-methyltetrahydrofolate.

Extrafolate-S® is the calcium salt of (6S)-5-methyltetrahydrofolate, and is suitable as a food ingredient.


Deficit of folate (a type of B vitamin) represents one of the most common forms of vitamin deficiency consequent on inadequate uptake, increasable needs (pregnancy and lactation, children growing), altered absorption and metabolism of drugs assumption.
Folate deficiency is related to reduction of cell's capacity to synthesize and repair DNA.

> Technical Information

Grade: Oral
Packing size: 1 Kg, 5 Kg LDPE bags
Regulatory status: GRAS, NDI
CAS number: 151533-22-1
Chemical name:
N-[4-[[[(6S)-2-amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-L-glutamic acid, calcium salt

Extrafolate-S® is the calcium salt of (6S)-5-methyltetrahydrofolic acid. It is intended for use as an alternative to folic acid in dietary supplements, foods for particular nutritional purposes and regular foods. It is the essential active form in which natural folates enter the human circulation, providing higher bioavailability and avoiding concerns about interaction between vitamin B12 and folic acid supplementation responsible for masking symptoms of vitamin B12 deficiency.


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