Fructose-1,6-disphosphate (FDP), is an important naturally occurring intracellular metabolite with a direct regulatory role in many metabolic pathways. In the human body FDP concurs to increase ATP, that plays a fundamental role in the creation of energy. The most important and widely studied of the FDP effects has been its regulation of glycolysis, particularly the enzyme that synthesizes FDP--phosphofructokinase (PFK).

Exogenous fructose 1,6-diphosphate (FDP), has been demonstrated to accelerate ATP production ,to prevent glycogen breakdown, to stimulate glycogen synthesis, and to synthesize free fatty acids in animals and humans.

FDP is used as pharmaceutical drug in the prevention and treatment of acute hypophosphatemia and phosphate depletion.

Obtained by fermentation FDP has been used since1958 in Italy, as powder to reconstitute or ready-to-use solution. It is classified in the Anatomic Therapeutic Chemical Classification as "Other cardiac preparations" (ATC code: C01EB07).

Fructose 1-6 diphosphate Trisodium salt lyophilized powder is indicated by parenteral use for short courses of treatment (3 to 5 days) in patients with hyphophosphatemia and/or chronic condition associated with phosphate depletion (transfusion, surgical interventions with extracorporeal circulation and parenteral nutrition during acute situations, metabolic distress states of skeletal muscle, prolonged malnutrition, chronic respiratory failure, chronic alcoholism) and ischemic cardiomyopathies.

Dicalcium, and Magnesium salt are also available.