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This solution offers advantages for the following functional areas:

Quatrefolic®, the InnovACTIVE Folate, is the glucosamine salt of the 5-methyltetrahydrofolate (5-MTHF), the metabolic active form of folate, available for its biological action, ubiquitous in all body cells and the only form of folate that directly crosses the blood-brain barrier.

Quatrefolic® maximizes the folate supplementation, overcoming the potential inability to benefit of both folic acid and 5-MTHF calcium salt supplementation for:

  • the partial inability of some people to convert folic acid to 5-MTHF
  • the related safety risk of folic acid accumulation in the blood as Unmetabolized Folic Acid (UMFA)
  • the related poor solubility and low stability of 5-MTHF calcium salt formulation

Key features

  • Biologically active: Quatrefolic® is the biologically active form of folate (5-MTHF) “ready to be used”; it completely bypasses the "damaged" MTHFR conversion step and delivers a "finished" folate the body can immediately use
  • Highly bioavailable: Quatrefolic® has shown higher bioavailability compared to calcium salt derivatives and folic acid
  • Soluble: Quatrefolic® is 100 times more soluble in water than 5-methyltetrahydrofolate calcium salt
  • Stable: Quatrefolic® does not need specific conditions of storage or handling
  • Safe: Quatrefolic® does not need any metabolization and does not expose cells to unmetabolized folic acid (UMFA)
  • Formulation flexibility: Quatrefolic® can be easily combined with other ingredients and excipients
  • For vegetarian consumers: Kosher and Halal Certified
  • Strong IP: US 7,947,662, EP 2245032 and EP 2254890 that covers applications and combinations with other actives

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