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Humans need to maintain an adequate dietary intake of folate during various stages of their lives because it is essential for cellular functions and health.

Right folate levels are critical when there is a high rate of cell turnover - such as in preconception and pregnancy (to prevent NTDs), lactation, infants and adolescents growth - for the correct brain functioning and nervous system (especially in mood impairment and cognitive functions in the elderly), in homocysteine metabolism disturbances, in men and female infertility, in increased metabolism in sport and many other conditions.

Humans cannot synthetize folate. Lower systemic folate levels can result from poor dietary intake, an increased need not matched by increased intake (such as pregnancy, lactation, child growth), various gastrointestinal disorders, drug use, chronic diseases, and a particular and serious genetic polymorphism of the methylenetetrahydrofolate reductase enzyme (MTHFR), involved in folate metabolism. The MTHFR enzyme is responsible for a key step of folate cycle where the biological active form 5-methyltetrahydrofolate (5-MTHF) is irreversibly produced, and is critical for right homocysteine metabolism.

People with this polymorphism do not produce adequate or effective form of the MTHFR enzyme with the consequence of impaired folate metabolism and exacerbation of folate deficiency. These genetic alterations are commonly frequent in global population.

The multidisciplinary research team at Gnosis has intensely studied this category of products and today Gnosis is the only manufacturer of three folate products that can claim GRAS status and NDIN with advanced chemical and clinical characteristics.

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